辣椒碱的抗炎镇痛作用研究

Study on anti-inflammatory and analgesic effect of capsaicin

目的研究辣椒碱对小鼠的镇痛、抗炎作用,为辣椒碱的临床应用和药物开发提供依据。方法采用热板法和扭体法作为镇痛实验模型以及鸡蛋清致炎的大鼠炎症模型,观察辣椒碱的镇痛抗炎作用。结果辣椒碱能显著减少醋酸所致小鼠扭体次数,延长小鼠热板致痛反应时间,对鸡蛋清引起的大鼠足跖肿胀有明显的抑制作用。结论辣椒碱具有镇痛抗炎作用。

Objective To investigate the analgesia and anti- inflammatory effect of capsaicin, provide basis for the development of new drugs and clinical applications. Methods Hot plate procedure and torsion body method were used as analgesia experimental model to observe the analgesic effect of Capsaicin. Ovi albumin induced inflammatory rat model was used to observe anti - inflammatory effect of Capsaicin. Results Capsaicincould reduce the number of stretch induced acetic acid in mouse and prolong time course of pain response induced by hot plate; and also had marked inhibitory effect on inflamed rats induced by ovi albumin. Conclusions Capsaicin has significant analgesia and anti -inflammatory effects.