腹腔镜联合大剂量甲氨蝶呤治疗宫外孕的效果分析

Effect analysis of combined application laparoscopic and high-dose methotrexate in treating extrauterine Pregnancy

目的评价腹腔镜联合大剂量甲氨蝶呤治疗宫外孕的效果,探索宫外孕理想的治疗方法。方法对2010年1月至2011年1月来院治疗宫外孕的100例患者进行宫外孕的治疗方法探索,按照随机分组的原则,将100例患者随机分为实验组和对照组,每组各50例患者。实验组采取腹腔镜下手术联合大剂量甲氨蝶呤治疗;对照组采取腹腔镜下手术联合常规剂量甲氨蝶呤治疗。统计分析对比两组患者在治疗效果方面的差异。结果治疗后,实验组住院时间和β-hCG下降速度及恢复正常时间,术后妊娠率均优于对照组,经检验以上评价指标的组间差异具有统计学意义(P<0.05),术后输卵管阻塞及通畅情况比较差异不显著,不具有统计学意义(P>0.05)。结论腹腔镜联合大剂量甲氨蝶呤治疗宫外孕,术后恢复情况良好且妊娠率较高,对患者的术后生活有着积极影响,可临床推广应用。

Objective To analyze the effect of combined application laparoscopic and high-dose methotrexate in the treatment of extrauterine pregnancy. Methods 100 patients with extranterine pregnancy were divided into objective group and control group. The control group was combined application laparoscopic and normal-dose methotrexate and the objective group was combined application laparoscopic and high-dose methotrexate. The difference of the surgery effect indicators between the two groups were compared. Results The postoperative β-HCG level of the objective group was lower than that in the control group. The length of time and the time of gastrointestinal functional recovery of the objective group were less than that in the control group. The postoperative pregnant rate of the objective group was better. Conclusions It would get a satisfactory effect to combined application laparoscopic and high-dose methotrexate in the treatment of extrauterine pregnancy, with the less body trauma and better prognostic level.