薏苡仁抗代谢综合征的药理作用研究进展

Research progress in Coicis Semen against metabolism syndrome

薏苡仁提取物及其有效成分对多种高血糖模型动物和高血脂肥胖模型动物均呈现出降糖、降脂作用,并能对抗高血糖、高血脂引起的代谢综合征及其并发症(包括氧化应激反应、动脉粥样硬化、脑缺血和免疫功能异常)。其有效成分包括薏苡仁多糖、羟基不饱和脂肪酸和多酚化合物,作用机制与提高葡萄糖激酶活性、促进组织对葡萄糖的利用、改善胰岛素抵抗和糖代谢紊乱,通过激活Nrf2/ARE依赖的细胞保护基因,对抗氧化应激性细胞损伤等有关。

Coicis Semen extract and its active constituents show hypoglycemic and hypolipidemic effects on various models of diabetic and hyperlipidemic obesity animals, and also effective in antagonism to metabolism syndrome induced by hyperglycemia and hyperlipidemia and its complications （oxidative stress, artherosclerosis, cerebral ischemia, and abnormal immune function）. Its active constituents include coixans, hydroxyl unsaturated fatty acid, and polyphenols. Its active mechanisms are relative to the enhancement of glucose utilization and glucokinase activity in tissue, improve the disorder of glycometabolism and insulin resistance, and to antagonize oxidative stress-induced cell injury by activation of Nrf2/ARE-depentent cytoprotective genes, and so on. Research progress in Coicis Semen and its active constituents with the function against metabolism syndrome is reviewed.