丹红注射液联合西药治疗慢性阻塞性肺疾病急性加重期随机平行对照研究

Randomized Controlled Study in Parallel with Chronic Obstructive Pulmonary Disease with Acute Exacerbation of Danhong Injection Combined with Western Medicine

[目的]观察丹红注射液联合西药治疗慢性阻塞性肺疾病急性加重期疗效。[方法]使用随机平行对照方法,将128例住院患者按掷骰子法随机分为两组。对照组64例常规治疗,祛痰、平喘、解痉、抗感染、纠正水电解质失衡。治疗组64例40mL丹红注射液+250mL0.9%生理盐水(或5%葡萄糖溶液),1次/d,静滴。西药治疗同对照组。连续治疗14d为1疗程。观测临床症状、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效55例,有效8例,无效1例,总有效率98.88%。对照组显效39例,有效16例,无效9例,总有效率85.94%。治疗组疗效优于对照组(P<0.05)。血液流变学指标两组均有改善(P<0.05),治疗组改善优于对照组(P<0.05)。[结论]丹红注射液联合西药治疗慢性阻塞性肺疾病急性加重期效果显著,值得推广。

[ Objective ] Observed Danhong injection combined with western medicine with acute exacerbation of chronic obstructive pulmonary disease effect. [ Methods] Random parallel control method, 128 cases of hospitalized patients were randomly divided into two groups according to the dice. Conventional treatment group 64 cases, expectorant, asthma, antispasmodic, anti-infection, correct water and electrolyte imbalance. Danhong treatment group 64 cases 40mL saline injection ＋250mL0.9% （ or 5% glucose solution ）, 1 times / d, intravenous infusion. Western medicine with the control group. 14d is a continuous course of treatment. Observing clinical symptoms of adverse reactions. A course of treatment to determine efficacy. Results ] The treatment group 55 cases were markedly effective, effective 8 cases, 1 had no effect, total effective rate was 98.88%. Control group 39 cases were markedly effective, effective in 16 cases, 9 no effect, the total effective rate was 85.94%. The treatment group curative effect is better than that of control group （P 〈0.05 ） . Hemorheology indexes in the two groups were improved （P〈0.05）, the treatment group is better than that of control group （P〈0.05） . Dan red injection with conventional therapy. [ Conclusion ] Danhong injection combined with western medicine treatment of chronic obstructive pulmonary disease with acute exacerbation of the effect is significant, it is worth promoting.