中医药及IL-18与不稳定型心绞痛

IL- 18 with Unstable Angina Progress

胸痹病机特点本虚标实,本虚涉及气血阴阳虚损,标实多为瘀血、痰浊;中药治疗可显著降低冠心病炎性因子血清IL-18浓度。炎症因子IL-18参与了冠状动脉粥样硬化的病理生理过程,水平的变化将会影响心血管事件的发生及发展。目前还缺少有关IL-18炎性因子在UA中动态变化的长期大规模临床观察,但是抗炎性因子治疗在理论上为UA提供了一种新的治疗策略,如能有效抑制IL-18炎性因子表达,可能会减少不良心血管事件发生,改善UA患者的预后。中医药治疗不稳定型心绞痛及血清白介素-18获得的疗效值得肯定,值得进一步研究探讨。

Obstruction of the pathogenesis characteristics of the virtual to real, this involves loss of Yin and Yang qi, the reality of blood stasis and phlegm turbidity; Traditional Chinese medicine treatment can significantly reduce inflammatory factor concentration of serum IL - 18 coronary heart disease. Inflammatory cytokines IL - 18 involved in the pathophysiological process of coronary atherosclerosis, the change of the level will affect the occurrence of cardiovascular events and development. At present also lacks the IL - 18 inflammatory factors of dynamic changes in the UA large-scale clinical observation for a long time, but some inflammatory factors treatment in theory to provide a new treatment strategy for UA, such as can effectively inhibit IL - 18 inflammatory factor expression, might reduce adverse cardiovascular events, improve the prognosis of patients with UA. Chinese medicine treatment of unstable angina and the curative effect of serum interleukin - 18 positive, deserves further research.