亮丙瑞林和曲普瑞林对体外受精-胚胎移植效果比较

THE EFFECT OF LEUPROLIDE VERSUS TRIPTORELIN ON IN VITRO FERTILIZATION AND EMBRYO TRANSFER

目的 探讨国产长效、短效促性腺激素释放激素激动剂（GnRH-a）亮丙瑞林、曲普瑞林在体外受精-胚胎移植（IVF-ET）中的降调效果。方法 回顾性分析2011年6月—2012年9月在我科接受长方案促排卵的154例IVF/卵细胞浆内单精子注射（ICSI）病人资料，其中57例（亮丙瑞林组）采用亮丙瑞林降调，97例（曲普瑞林组）采用曲普瑞林降调。结果 两组均达到降调标准，但月经第2天血清雌二醇（E2）、卵泡刺激素（FSH）、黄体生成素（LH）水平比较差异均有统计学意义（t=2.217-3.665，P〈0.05）。两组促性腺激素（Gn）用量及天数、绒毛膜促性腺激素（HCG）日血清LH及孕酮（P）水平比较差异均有统计学意义（t=4.599-6.114，P〈0.05）；HCG日血清E2水平比较差异无统计学意义（P〉0.05）。两组获卵数、受精率、优胚率、妊娠率比较差异均无统计学意义（P〉0.05）。结论 在IVF-ET长方案促排卵治疗中，国产亮丙瑞林1.2 mg黄体中期皮下注射可达到垂体降调节标准，与国产曲普瑞林具有相同的临床治疗效果。

Objective To assess the effect of domestic long-and short-acting GnRH-a-Leuprolide and Triptorelin-on down regulation in in-vitro fertilization and embryo transfer （IVF-ET）. Methods A retrospective analysis was done in clinical data of 154 patients who received long protocol IVF intracytoplasmic sperm injections （ICSI）, of whom, 57 received subcutaneous injection of leuprolide for down regulation, while 97 received triptorelin .Results The levels of serum E2, FSH and LH on day 2 at menstruation were statistically different between Leuprolide and Triptorelin groups, all reached the standard of pituitary down-regulation （t=2.217-3.665,P〈0.05）. The differences between the two groups were significant in terms of dosage of Gn, the levels of serum LH and P on the day of HCG （t=4.599-6.114,P〈0.05）, while there was not in terms of serum E2 （P〉0.05）. There were no significant differences between the two groups in regard to number of retrieved oocytes, fertilization, high quality embryos and clinical pregnancy rate （P〉0.05）.Conclusion In long protocol IVF-ET of ovulation induction, subcutaneous injection of 1.2 mg domestic Leuprolide in the middle of luteal phase is effective in controlling pituitary down-regulation and achieving same clinical outcomes as Triptorelin does.