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思茅红椿化学成分及其抗炎活性研究 被引量:2

Chemical constituents from Toona ciliata var.henryi and their anti-inflammatory activities
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摘要 目的研究思茅红椿Toona ciliata var.henryi茎皮的化学成分及其抗炎活性。方法采用硅胶柱色谱、Sephadex LH-20柱色谱、反相C18柱色谱等分离纯化,利用理化性质和波谱学数据鉴定化合物结构,并对部分化合物进行抑制脂多糖(LPS)诱导RAW264.7细胞释放NO活性的测定。结果从思茅红椿茎皮的95%乙醇提取物中分离得到15个化合物,分别鉴定为odoratone(1)、toonaciliatinF(2)、toonaciliatinG(3)、toonaciliatinJ(4)、hispidone(5)、bourjotinoloneA(6)、3-episapelineA(7)、piscidinolA(8)、aglaiodiol(9)、toonaciliatinM(10)、2α,19-dihydroxy-9-epi-ent—pimara-7,15-diene(11)、cleomiscosinB(12)、cleomiscosinC(13)、13-谷甾醇(14)、13-胡萝h苷(15)。化合物4和10抑制LPS诱导RAW264.7细胞释放NO的Ic铀值为(11.0±0.7)和(28.8±2.7)pmol/L。结论所有化合物均为首次从该植物中分离得到,化合物11~13为首次从该属植物中分离得到。其中化合物4和10对LPS诱导RAW264.7细胞释放NO显示出了中等的抑制作用。 Objective To study the chemical constituents from Toona ciliata var. henryi and their bioactivities. Methods Column chromatography on silica gel, RP-CIs, and Sephadex LH-20 columns was used to separate and purify the chemical constituents. The structures were elucidated by physicochemical properties and spectroscopic analyses. These compounds were isolated and evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells. Results Fifteen compounds were isolated from the stem barks of Z ciliata var. henryi and identified as odoratone (1), toonaciliatin F (2), toonaciliatin G (3), toonaciliatin J (4), hispidone (5), bourjotinolone A (6), 3-episapeline A (7), piscidinol A (8), aglaiodiol (9), toonaciliatin M (10), 2α, 19-dihydroxy-9-epi-ent-pimara-7, 15-diene (11), cleomiscosin B (12), cleomiscosin C (13), 13-sitosterol (14), and β-daucositerol (15). The ICs0 values of compounds 4 and 10 were (11.0 ± 0.7) and (28.8 ± 2.7) μmol/L. Conclusion All the compounds are isolated from this plant for the first time. Compounds 11--13 are yielded from the plants of Toona Roem. for the first time. Compounds 4 and 10 show the moderate inhibitory activities.
出处 《中草药》 CAS CSCD 北大核心 2014年第6期755-759,共5页 Chinese Traditional and Herbal Drugs
基金 国家自然科学基金资助项目(U1204830) 河南省教育厅科学技术研究重点项目资助计划项目(13A310064) 河南大学科学研究基金项目(2012YBZR035)
关键词 思茅红椿 抗炎 toonaciliatin J Β-谷甾醇 β-胡萝卜苷 Toona ciliata Roem. var. henryi (C. DC.) C. Y. Wu anti-inflammation toonaciliatin J β-sitosterol β-daucositerol
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参考文献23

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