TCT,HC2-HPV-DNA检测和阴道镜检查在宫颈癌及癌前病变筛查中的联合应用

TCT combined with HC2- HPV- DNA and colposcopy in the screening for cervical cancer and precancerous lesion

目的:探讨TCT,HC2-HPV-DNA检测和阴道镜检查在宫颈癌及癌前病变筛查中的联合应用价值。方法:1236例女性作为研究对象,依次进行HC2-HPV-DNA检测、TCT检查、阴道镜检查和病理学检查。结果:HC2-HPV-DNA检测,TCT和阴道镜检查的阳性率均显著小于病理学检查阳性率(χ2=40.084,P<0.01;χ2=45.008,P<0.01;χ2=50.344,P<0.01),上述三项检查中,均为阳性者19例(1.5%),任意两项阳性者35例(2.8%),任意一项阳性者78例(6.3%)。结论:TCT,HC2-HPV-DNA检测和阴道镜检查均有一定的局限性,但上述方法联合应用将大大提高筛出率,为患者及时治疗赢得宝贵时间。

Objectives： To explore the value of TCT combined with HC2-HPV-DNA and colposcopy in the screening for cervical cancer and the precancerous lesions.Method： 1236 women were selected and given HC2 -HPV-DNA test,TCT test and colposcopy test.Pathological examination was conducted on the samples which showed positive restlts in each of the above 3 tests.Results： The positive rates of the 3 tests were all lower than the rates shown in the pathological examinations （x2 =40.084; P ＜0.01 ;x2 =45.008; P ＜0.01 ; x2 =50.344; P ＜0.01）.There were 19 cases showing positive results in the 3 tests （1.5％） ; 35 cases showing positive in 2 tests （2.8％） ; and 78 cases showing positive in 1 test （6.3％）.Conclusion： All the 3 tests have their limitations.The combining of them can significantly enhance positive rate for earlier and more accurate detection.