50例进展期结直肠癌新辅助化疗的疗效及对预后的影响

The influence of prognosis and efficacy of neoadjuvant chemotherapy on 50 patients with advancedcolorectal cancer

目的分析新辅助化疗对进展期结肠癌的疗效及对预后的影响。方法选取进展期结肠癌的患者50例，随机分为实验组和对照组，对照组采用常规药物化疗方法，实验组在此基础上再进行新辅助化疗，1个月后观察两组患者癌细胞的转移、复发及不良反应的发生。结果患者进行不同方法的治疗1个月后，对照组患者出现复发（64．00％）和转移（72．00％）的发生率明显高于实验组患者出现复发（16．00％）和转移（12．00％）的发生率，差异有统计学意义（P〈0．05），并且对照组患者不良反应的发生率（84．00％）明显高于实验组（20．00％），差异有统计学意义（P〈0．05）。结论对进展期结肠癌的患者采用新辅助化疗的方法可以降低复发、转移和不良反应的发生率，疗效明显，可以在临床上推广应用．．

Objective To analyze the efficacy of neoadjuvant chemotherapy on 50 patients with advanced colorectal cancer and its influence on prognosis. Methods Fifty patients with advanced color ectal cancer were randomly divided into experimental group and control group, the patients in control group were given general drug chemotherapy, the patients in experimental group were given the neoadju vant chemotherapy on the basis of general drug chemotherapy. After one month, the incidence of cancer cell metastasis, recurrence and adverse reactions of the two groups were observed. Results After one month, the incidences of recurrence （64.00%） and metastasis （72.00%） were significantly higher in the control group than the incidence of recurrence （ 16.00% ） and metastasis （ 12.00% ） in the experi ment group, there were significant differences（P 〈 0.05） , and the incidence of adverse reactions in the control group（84. 00% ） was significantly higher than that in the experimental group （20. 00% ）, there was significant difference （P 〈 0. 05 ）. Conclusions The method of neoadjuvant chemotherapy in treat ment of patients with advanced colorectal cancer can reduce the incidence of recurrence, metastasis, and adverse reactions, which had obvious effect and can be used in clinics.