摘要
Pancreatic cancer is a fatal malignancy with an increasing incidence in Shanghai, China. A genomewide association study(GWAS) and other work have shown that ABO alleles are associated with pancreatic cancer risk. We conducted a population-based case-control study involving 256 patients with pathologically confirmed pancreatic ductal adenocarcinoma(PDAC) and 548 healthy controls in Shanghai, China, to assess the relationships between GWAS-identified ABO alleles and risk of PDAC. Carriers of the C allele of rs505922 had an increased cancer risk [adjusted odds ratio(OR) = 1.42, 95% confidence interval(CI): 1.02-1.98] compared to TT carriers. The T alleles of rs495828 and rs657152 were also significantly associated with an elevated cancer risk(adjusted OR = 1.58, 95% CI: 1.17-2.14; adjusted OR = 1.51, 95% CI: 1.09-2.10). The rs630014 variant was not associated with risk. We did not find any significant gene-environment interaction with cancer risk using a multifactor dimensionality reduction(MDR) method. Haplotype analysis also showed that the haplotype CTTC was associated with an increased risk of PDAC(adjusted OR = 1.46, 95% CI: 1.12-1.91) compared with haplotype TGGT. GWAS-identified ABO variants are thus also associated with risk of PDAC in the Chinese population.
Pancreatic cancer is a fatal malignancy with an increasing incidence in Shanghai, China. A genome wide association study （GWAS） and other work have shown that ABO alleles are associated with pancreatic cancer risk. We conducted a population-based case-control study involving 256 patients with pathologically confirmed pancreatic ductal adenocarcinoma （PDAC） and 548 healthy controls in Shanghai, China, to assess the relationships between GWAS-identified ABO alleles and risk of PDAC. Carriers of the C allele of rs505922 had an increased cancer risk [adjusted odds ratio （OR） = 1.42, 95% confidence interval （CI）： 1.02-1.98] compared to TT carriers. The T alleles of rs495828 and rs657152 were also significantly associated with an elevated cancer risk （adjusted OR = 1.58, 95% CI： 1.17-2.14; adjusted OR = 1.51, 95% CI： 1.09-2.10）. The rs630014 variant was not associated with risk. We did not find any significant gene-environment interaction with cancer risk using a multifactor dimensionality reduction （MDR） method. Haplotype analysis also showed that the haplotype CTTC was associated with an increased risk of PDAC （adjusted OR = 1.46, 95% CI： 1.12-1.91） compared with haplotype TGGT. GWAS-identified ABO variants are thus also associated with risk of PDAC in the Chinese population.
基金
supported by the U.S.National Cancer Institute(5R01CA114421)
the Science and Technology Commission of the Shanghai Municipality(08411954100)
关键词
中国人群
基因多态性
全基因组
胰腺癌
风险
关联
导管
评估
Key words Pancreatic ductal adenocarcinoma, ABO gene, genome-wide association study, genetic variation, haplotype
