超声引导下注射不同剂量凝血酶治疗血管介入诊疗术后股动脉假性动脉瘤的临床观察

Clinical observation of ultrasound guided injection different dosage of thrombin for treatment of iatrogenic femoral artery pseudoaneurysm

目的探讨超声引导下注射不同剂量凝血酶治疗血管介入诊疗术后股动脉假性动脉瘤的疗效和不良反应。方法将48例于襄阳市中心医院行血管介入术后形成股动脉假性动脉瘤的患者随机分为两组,观察组注射凝血酶液为100 U/ml,对照组注射凝血酶液为500 U/ml,在超声引导下于瘤腔内注射凝血酶。结果观察组和对照组患者特征、注射凝血酶次数及操作时间差异无统计学意义,观察组有1例术后1天复发,对照组全部成功。对照组有2例发生股浅动脉栓塞,1例术后1周内有低热,观察组无不良反应发生。结论在超声引导下注射凝血酶治疗血管介入诊疗术后股动脉假性动脉瘤,小剂量注射凝血酶同样有效,而且可能降低注射凝血酶的风险。

Objective To investigate the efifcacy and adverse effect of ultrasound-guided injection of different dosage of thrombin in the treatment of femoral artery pseudoaneurysm formed after vascular intervention. Methods 48 cases of femoral artery pseudoaneurysm after vascular interventional operation in our hospital were randomly divided into two groups according to the dosage thrombin given.Under ultrasound guidance, patients in the observation group （n=24） received injection thrombin 100U/ml while patients in the control group received injection of thrombin 500U/ml.All the operational procedures were identical between the 2 groups. Results No statistical differences were found in clinical characteristics, total number injection needed and operation time between two groups.Recurrence pseudoaneurysm was noted in 1 cases in the observation group. 2 cases of superifcial femoral arteries thrombin and 1 case of fever were recorded in control group. There was no difference in adverse event rates between the 2 group. Conclusions Ultrasound-guided injection with low dose thrombin in the treatment of post interventional femoral artery pseudoaneurysm is equally effective as higher dose.