戒烟与吸烟对肺腺癌生存期影响的相关性研究

Study of the influence of smoking-cessation and smoking on overall survival of pulmonary adenocarcinoma

目的研究戒烟与吸烟对肺腺癌生存期(overall survival,OS)的影响。方法回顾分析2008年2月至2013年2月就诊于大连医科大学附属二院的肺腺癌患者的临床资料,根据患者确诊前后是否戒烟、吸烟指数对152例患者进行分组,采用电话随访的方式统计患者的生存期并进行统计学分析。结果确诊前后戒烟的患者有较好的预后,其生存期较未戒烟患者长(χ2=3.99,P=0.046);吸烟指数的大小对肺腺癌预后的影响差异无统计学意义(P>0.05)。结论戒烟对肺腺癌患者的预后有着重要的意义,鼓励确诊患者戒烟可延长患者的生存期。

Abstract： Objective To analyze the influence of smoking-cessation and cigarette smoking on the overall sulvival （OS） of pulmonary adenoearcinoma. Methods 152 patients with puhnonaly adenocarcinoma admitted fk＇om Feb. 2008 to Feb. 2013 in the Second Affiliated Hospital of Dalian Medical University were divided into groups by smoking status and smoking index ; Their clinical data were retrospectively reviewed. The information on OS was collecled through case records or follow up phone calls, and then analyzed with SPSS. Results The patients who had quitted smoking showed a better prognosis and longer OS （χ2 = 3.99, P = 0. 046） ; there was no statistical significance between the subgroups of cigarette smoking index （P 〉 0.05）. Conclusion Smoking-cessation makes better prognosis for pulmonary adenoearcinoma; Diagnosed patients should be encouraged to quit smoking to prolong their OS.