三阴性乳腺癌的临床病理特征分析

Analysis of clinicopathological features in triple negative breast cancer

目的:探讨三阴性乳腺癌(triple negative breast cancer,TNBC)的临床病理特点,以及TNBC中突变型p53的表达及其意义。方法:回顾性分析195例乳腺癌病例,按雌激素受体、孕激素受体、人表皮生长因子受体2的表达分为TNBC组34例和对照组161例。检测TNBC组织中突变型p53的表达,分析其与TNBC临床病理特征及预后的关系。结果:TNBC组病人的复发转移率较高(29.4%比1.2%,P<0.001)、无病生存率显著低于对照组(52.9%比90.7%,P<0.001)。TNBC组突变型p53阳性表达率明显高于对照组(47.1%比22.4%,P<0.01),且突变型p53阳性表达与TNBC腋窝淋巴结转移有关(77.8%比36.0%,P<0.05)。结论:TNBC乳腺癌复发转移率高,无病生存率较低,预后较差。TNBC组织中突变型p53表达上调,其可作为TNBC重要的预后指标。

Objective To investigate the clinicopathological features and the expression of mutated p53 protein in the patients with triple negative breast cancer（TNBC）. Methods There were 195 cases studied retrospectively including 34 cases in TNBC group and 161 cases in control group（non-TNBC） by the tests of expression of estrogen receptor and progesterone receptor and human epidermal growth factor receptor-2. The expression of mutated p53 protein was also detected. Results The higher both recurrence and metastasis and shorter time of disease free survival of the patients in TNBC group were found compared with those in control group （29.4% vs 1.2%, P〈0.001）. The rate of the patients with desease free survival in TNBC group was less than that in control group （52.9% vs 90.7%, P〈0.001）. The patients with the expression of mutated p53 protein in TNBC group was more than that in control group （47.1% vs 22.4%, P〈0.01）. Conclusions The patients with TNBC may have poor prognosis. Expression of mutated p53 in TNBC could be regarded as an important biomarker for prognosis.