肝门部恶性梗阻性黄疸的介入治疗

Interventional therapy for hilar malignant obstructive jaundice

目的:探讨介入治疗肝门部恶性梗阻性黄疸的临床疗效。方法:收集2012年7月至2013年6月郑州大学第一附属医院收治的22例肝门部恶性梗阻性黄疸患者临床资料,所有患者均接受经皮肝穿刺胆道引流(percutaneous transhepatic cholangial drainage,PTCD)治疗,比较患者治疗前后血清总胆红素的变化,评价疗效。计量资料用t检验。结果:介入治疗成功率为100%。治疗后2周血清总胆红素下降明显(P<0.05)。术后并发症7例,给予相应治疗后症状消失,无严重并发症发生。结论:PTCD术治疗肝门部恶性梗阻性黄疸可有效缓解黄疸症状,患者耐受性良好,为后续抗肿瘤治疗提供机会。

Objective： To evaluate the clinical efficacy of interventional therapy for hilar malignant obstructive jaundice. Methods： 22 patients with hilar malignant obstructive jaundice were treated by percutaneous transhepatic cholangial drainage（PTCD） in the First Affiliated Hospital ofZheng- zhou University from July 2012 to June 2013. The clinical efficacy was evaluated by comparing the preoperative and postoperative levels of bilirubin. Results： All the patients were operated success- fully. The total bilirubin levels descended obviously after two weeks （ P 〈 0.05 ）. 7 patients had complications and the symptoms disappeared after corresponding treatment. Conclusion ： PTCD for hilar malignant obstructive jaundice could relieve symptoms caused by jaundice. Patients had good tolerance. PTCD may provide opportunities for subsequent antitumor therapy.