Nd:YAG1064nm激光、伊曲康唑治疗轻中度甲真菌病近期疗效分析

The efficacy of laser therapy,drug therapy in the treatment for mild or moderate onychomycosis

目的观察Nd:YAG1064nm激光治疗机、伊曲康唑治疗甲真菌病的有效性及安全性。方法选取符合入组条件的患者60例,病甲共125个。将60例患者随机分为A、B两组,A组予以Nd:YAG1064nm激光治疗;B组予以伊曲康唑口服治疗。每组均于第8周、第16周、第24周时随访,随访时予以真菌学评价及临床疗效评价。结果 A组第8周、16周、24周有效率分别为78.9%、52.6%、52.6%,B组第8周、16周、24周有效率分别为80.9%、66.2%、67.6%。A、B两组临床疗效差异无统计学意义(P>0.05)。结论激光治疗甲真菌病疗效肯定,且无不良反应。在轻中度甲真菌病患者中,激光治疗和药物治疗有效率差异不大。

Objective To observe the efficacy and safety of Nd：YAG 1064 nm laser therapy,itraconazole therapy in the treatment for onychomycosis.Method Sixty patients with 125 nails infected by fungi were randomly assigned to two groups.The nails in group A were treated by Nd：YAG 1064 nm laser.The nails in group B were treated by itraconazole.By following the patients of each group at 8 weeks,16 weeks,and 24 weeks,both clinical and mycological efficacy was evaluated.Results In group A,the effective rates at 8 weeks,16 weeks,and 24 weeks were 78.9%,52.6% and 52.6% respectively.In group B the effective rates were 80.9%,66.2% and 67.6% respectively.There was no significant difference in the treatment efficacy between the two groups （P 〈0.05）.Conclusion Long pulse Nd：YAG 1064 nm laser therapy was a simple and effective method without significant complications or side effects.The difference in the treatment efficacy between the laser therapy and the drug therapy for patients with mild or moderate onychomycosis was not significant,so laser therapy could be considered in first-line therapy.