紫外线对白念珠菌的影响

The effect of UV on Candida albicans

紫外线作为重要的环境因子之一,能显著影响包括白念珠菌在内的多种生物的生长及生理过程。研究发现白念珠菌受紫外线照射后菌丝形成被抑制,孢子形成增多且没有向光性;脉冲紫外线辐射可通过多靶点程序使白念珠菌失活;rad 51缺陷株比rad 52缺陷株更易受紫外线损害,同时紫外线可导致白念珠菌杂合性丢失。研究还发现UVC治疗可明显减少烧伤后真菌微生物感染,核黄素/UVA治疗可明显抑制白念珠菌生长。因此紫外线对白念珠菌有一定的抑制作用。

Ultraviolet as one of the important environmental factors is significant to the growth and the physiological reactivity of many organisms including Candida albicans.It was found that the progression of hyphal growth was inhibited,formation of spore was increased and no phototropic effects were seen; PL-irradiation inactivated Candida albicans strains through a multi-targeted process,What＇s more,null strains of rad 51 was more susceptible to UV damage than the rad 52 null and loss of heterozygosity was induced in Candida albicans by ultraviolet irradiation.In addition,statistical analysis demonstrated that UVC treatment significantly reduced the fungal microbial infection after burns; growth inhibition zone was significantly greater after treatment with riboflavin/UVA.So the influence of UV is remarkable to Candida albicans.