摘要
异基因造血干细胞移植(allogenic hematopoietic stem cell transplantation,allo-HSCT)是目前治疗造血系统各种恶性疾病或非恶性增殖性疾病的有效方法,但是移植物抗宿主病(graft versus host disease,GVHD)的发生限制了造血干细胞移植的成功率,其中慢性移植物抗宿主病(chronic graft versus host disease,cGVHD)是影响造血干细胞移植后受者长期生存率和生活质量的主要因素。本文从胸腺、细胞因子、T淋巴细胞各亚群和B淋巴细胞及其分泌的抗体四个方面对cGVHD的发病机理及相关领域的最新研究进展作一综述。
Allogeneic hematopoietic stem cell transplantation （allo-HSCT） is an effective method for the treating of malignant diseases of hematopoietic system or non-malignant proliferative diseases, but the occurrence of graft-versus- host disease （GVHD） limits the success rate of hematopoietic stem cell transplantation. Moreover, chronic graft-versus- host disease （cGVHD） is the main factor affecting the long-term survival rate and life quality of recipient after hematopoietic stem cell transplantation. In this article, the latest research progress of the pathogenesis of cGVHD and related problems are reviewed from the thymus, cytokines, T lymphocyte subsets, B lymphocytes and its secreted antibody.
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2014年第2期549-554,共6页
Journal of Experimental Hematology
基金
国家自然科学基金面上项目(81371945
81371945
31070996
31171084)
国家自然科学基金青年项目(81101342)
北京市自然科学基金面上项目(7132133)
关键词
造血干细胞移植
慢性移植物抗宿主病
发病机制
hematopoietic stem cell transplantation
chronic graft-versus-host disease
pathogenesis
