川芎及其配方颗粒中阿魏酸的含量比较

Comparison of Contents of Ferulic Acid between Rhizoma Chuanxiong and Its Dispensing Granules

目的:比较川芎及其配方颗粒中主要成分阿魏酸的含量。方法:采用HPLC法,以Waters SunFire C18(4.6mm×250mm,5μm)为色谱柱,甲醇-1%醋酸溶液(30∶70)为流动相,流速为0.8ml/min,检测波长321nm,柱温为30℃,测定川芎饮片及其配方颗粒中阿魏酸的含量,比较二者含量差异。结果:川芎饮片中阿魏酸的含量低于《中国药典》规定,配方颗粒中阿魏酸的含量远低于原药材的含量,与所标示的浓缩倍数不符。讨论:配方颗粒的生产工艺需要改进;需要建立统一的质量控制方法和合理的质量标准。

Objective： To compare the contents of ferulic acid between Rhizoma Chuanxiong and its dispensing granules. Methods ： A Waters SunFire C ls （4.6 mmx 250 mm, 5 μm） was used for the analysis. The separation was performed with mobile phase of Methanol - 1% Acetic acid （ 30：70 ） at the flow rate of 0.8mL/min ; the column was thermosttated at 30℃ and the detection wavelength was set at 321nm; HPLC was used to determine the contents of ferulic acid between Rhizoma Chuanxiong and its dispensing granules, and compare the difference between two contents. Results： The contents of ferulic acid in Rhizoma Chuanxiong were less than the limitation of pharmarcopoeia in China ; The contents of ferulic acid in dispensing granules were less than Rhizo- ma Chuanxiong , and the daily amounts of the major components in dispensing granules were not equivalent in the decoction of Rhizoma Chuanxiong. Conclusion：The original dispensing granule productive process needs to be improved;the standardized criteria for the quality control of dispensing granules should be established and the manufacturing process, the criteria for raw material selection should be assessed and improved.