胰岛素泵皮下注射和多次胰岛素皮下注射治疗妊娠期糖尿病疗效的比较

Comparison of therapeutic effects on gestational diabetes mellitus between continuous subcutaneous insulin infusion and multiple subcutaneous insulin injection therapy

目的分析胰岛素泵连续皮下输注(CSII)治疗妊娠期糖尿病(GDM)的临床效果。方法选择GDM和糖尿病合并妊娠患者共103例,分为CSII组和胰岛素多次皮下注射(MSII)组,比较两组血糖控制情况及母婴并发症的发生情况。结果治疗5d后,两组FPG、1hPG、2hPG,28、36周HbA1c,血糖达标天数,胰岛素用量比较,差异均有统计学意义(P<0.01)。两组母体低血糖、早产的发生率及胎儿低血糖的发生率比较,差异均有统计学意义(P<0.05或P<0.01)。结论胰岛素泵可更快、更平稳地控制GDM和糖尿病合并妊娠患者的血糖,并可减少低血糖的发生,其临床应用效果优于传统的胰岛素多次皮下注射方式。

Objective To analyze the clinical effects on gestational diabetes mellitus between continuous subcutaneous insulin infusion （CSII） and multiple subcutaneous insulin injection（MSII）. Methods 103 patients with gestational diabetes meIlitus were divided into CSII group and MSII group. The blood glucose control state and the occurrence rates of maternal and fetal complications were compared between the two groups. Results The differences in FPG, 1 hPG, 2 hPG after 5 days of treatment, HbAa c at 28 and 36 weeks, the target time of blood glucose, insulin dosage, the incidence of preterm and fetus and maternal hypoglycemia were statistically significant between the two groups （P〈0. 05 or P 〈0. 01）. Conclusion CSII is superior to MSII therapy for blood glucose control and the occurrence rate of hypoglycemia, its clinical effect is better than that in traditional insulin subcutaneous injection.