类风湿性关节炎动物模型的研究进展与中药药效评价思考

Advances in Establishments of Animal Models with Rheumatoid Arthritis and Thinking about Efficacy Evaluation of TCM

目的介绍类风湿性关节炎模型的研究进展,进行中药药效评价思考。方法对近十几年来国内外相关文献对关节炎模型的报道进行整理、分析与归纳。结果与结论目前主要有佐剂性关节炎和胶原诱导性关节炎模型等,应该根据中药自身的特点选择合适的动物模型,进行候选药物筛选和药效评价,并将类风湿性关节炎动物模型的研究与临床疾病研究紧密地结合起来,为临床前中药药理研究与药效评价提供方法学保证。

Objectiv e To introduce the research development on the establishments of animal models with rheumatoid arthritis, and think about efficacy evaluation of TCM. Methods References in the last decades at home and abroad about RA model were collated, analyzed and summarized. Results and Conclusion The main KA model are AA, CIA and so on. We should select suitable animal model on the basis of TCM＇s characteristic to screen out medicine and to evaluate the efficacy of medicine, and combine closely the research of RA＇s animal model with clinical disease to ensure the stability and reliability of animal model. And then to offer methodological ensurance for TCM＇s pharmacological preclinical research and efficacy evaluation.