脂肪酸合酶抑制剂的减肥作用研究进展

Research Advances of Reducing Weight Effect of FAS Inhibitors

肥胖已成为全球发病率较高的一种疾病,它与高血压、高血脂、糖尿病等疾病的发病密切相关。脂肪酸合酶(Fatty acid synthase,ab.FAS)是催化内源性长链脂肪酸合成的关键酶。FAS在人的脂肪组织中有较高的表达,目前已成为治疗肥胖症等疾病的重要靶点。总结了C75和S8、天然药物提取物以及水果、蔬菜和调料提取物对脂肪酸合酶的抑制以及其表现出的减肥作用。

Obesity has become a disease of high morbidity in the world, closely related to high blood pressure, high cholesterol,and diabetes. Fatty acid synthase （FAS） is the key metabolic enzyme catalyzing the synthesis of long chain saturated fatty acids. FAS has become an important target now to treat obesity and other diseases because of its high ex- pression in the fatty tissue. This article summarized the research advances of FAS inhibitions of C75, S8 and extracts from natural plants, fruits, vegetables and spices.