中药联合地西他滨治疗高危型骨髓增生异常综合征临床观察

Clinical Efficacy of Chinese Medicine Combined with Decitabine in Treatment of High Risk Myelodysplastic Syndromes

目的:探讨中药联合地西他滨治疗高危型骨髓增生异常综合征(MDS)的临床疗效观察,并与单用地西他滨组的治疗对照。方法:收集近3年在医院血液科治疗的高危型MDS患者30例,静滴地西他滨20 mg/(m2·d),连用5 d,观察组在使用地西他滨的基础上联合中草药治疗,测评治疗前后外周血象、完全缓解率及其疗效、不良反应,对比两组治疗的差异。观察地西他滨治疗高危型MDS的总体疗效及安全性。结果:观察组临床完全缓解率18.75%,单用西药组为21.42%,两组无明显统计学差异。观察组能够改善药物不良反应,相较于单用西药组,能明显改善"感染率"、"ANC时间"、"Plt减少时间","临床出血症状","消化道反应"、"口腔黏膜炎",提高患者生活质量。结论:中药联合地西他滨治疗高危型MDS患者,能明显改善药物不良反应,减少并发症,疗效安全持久。

Objective：To assess the clinical efficacy of Chinese medicine combined with decitabine for the treatment of patients with high risk myelodysplastic syndromes （ MDS）, and compare with single western medicine group. Methods ： Thirty consecutive patients with high - risk MDS were enrolled from Shuguang Hospital in recent three years and were treated with 5 -day decitabine intravenous injection （ 20 mg/m2, once a day） . Observation group added Chinese medi- cine treatment. Before and after treatment, the peripheral blood routines, clinical complete remission rate and its efficacy and adverse reactions were evaluated for the analysis and comparison of differences in treatment of the two groups. The effect and safety of decitabine in the treatment of high - risk - of myelodysplastic syndrome were observed. Results ： Chi- nese medicine group＇ s clinical full mitigation rate was 18.75%, and that of signle Western medicine group was 21.42%. The two groups had no significant statistical difference. Chinese medicine combined with decitabine for the treatment of patients with high risk myelodysplastic syndromes （MDS） can improve drug side effects and can obviously improve infec- tion rate,ANC time, PLT reduced time, clinical bleeding symptoms, digestive road reaction and oral mucosa inflammatory, and can improve patients＇ life quality. Conclusion ： Combined with decitabine in the treatment of traditional Chinese medi- cine in patients with high -risk MDS can significantly reduce adverse reactions,reduce complications and the effect is of persistent security.