氯吡格雷联合阿司匹林序贯疗法对老年短暂性脑缺血发作二级预防疗效及安全性

Efficacy and safety of sequential therapy of clopidogrel and aspirin for secondary prevention of transient ischemic attack in elderly patients

目的评价氯吡格雷联合阿司匹林序贯疗法对老年短暂性脑缺血发作(TIA)二级预防的疗效及安全性。方法将128例老年TIA患者按数字表法随机分为对照组和观察组各64例,对照组给予阿司匹林抗栓,观察组联合氯吡格雷序贯治疗,对比两组疗效及安全性。结果观察组近、远期疗效均明显优于对照组,两组APTT、PT血清水平均明显升高,FIB、DD血清水平均显著降低,但观察组改善均更为明显,差异均有统计学意义(P<0.05),两组安全性差异无统计学意义(P>0.05)。结论氯吡格雷联合阿司匹林序贯疗法可显著改善老年TIA患者凝血、纤溶系统,疗效确切,安全性高,值得优先选用。

Objective To evaluate the efficacy and safety of sequential therapy of clopidogrel and aspirin for secondary prevention of elderly patients with transient ischemic attack （TIA）. Methods The 128 elderly patients with TIA were randomly assigned to the control group and the observation group by random number table, with 64 patients in each group. The control group was given aspirin as antithrombotic agent and the observation was given sequential therapy of clopidogrel and aspirin. The efficacy and safety were compared between the two groups. Results The observation group had better short-term and long-term efficacy than the control group. Both groups had significant increase of serum AP＇IT and PT and decrease of serum FIB and DD, but the observation group had better improvement than the control group, with statistical significance （P〈0.05）. The two groups had no significant difference with regard to therapeutic safety （P〉0.05）. Conclusion Sequential therapy of clopidogrel and aspirin can significantly improve the coagulation system and the fibrinolytic system of elderly patients with TIA. It has significance efficacy and high safety, thus it is worthy to be considered as first choice.