HA、PT和PLT联合检测在慢性乙型肝炎肝硬化患者中的临床应用分析

Clinical application of HA, PT and PLT combination detection in patients with chronic hepatitis B liver cirrhosis

目的探讨慢性乙型肝炎肝硬化患者透明质酸(HA)、凝血酶原时间(PT)及血小板计数(PLT)联合检测的临床诊断价值。方法选取慢性乙型肝炎患者53例、慢性乙型肝炎肝硬化患者75例、健康体检者40例(对照组),回顾性分析每组HA、PT及PLT指标;根据Child-Pugh标准对肝硬化组分级,其中A级42例,B+C级33例;肝硬化组选取合并上消化道出血组和未出血组,比较HA、PT及PLT在各组中的差异。结果乙型肝炎肝硬化患者PT、HA较慢性乙型肝炎组和健康组明显提高,PLT明显降低;肝硬化B+C级患者组HA、PT及PLT异常水平高于肝硬化A级患者组,差异均具有统计学意义(P<0.05)。出血组与未出血组相比,HA无明显差异,PT和PLT差异有统计学意义(P<0.05)。结论 PT、HA、PLT的联合检测可以反映肝损程度和病情轻重,在指导临床对肝硬化的诊断及治疗上有重要参考价值。

Objective To investigate hyaluronic acid （HA）, prothrombin time （PT） and platelet count （PLT） combi- nation detection in patients with chronic hepatitis B cirrhosis of the liver for clinical diagnostic value. Methods Select- ed cases were divided into 53 cases of chronic hepatitis B patients, 75 cases of patients with chronic hepatitis B cirrho- sis of the liver, the healthy check-up of 40 cases （control group）, each group of HA, PT and PLT index were retro- spectively analyzed; The liver cirrhosis group was divided into A level of 42 cases, B ＋ C level 33 cases according to the Child - Pugh standard. The liver cirrhosis group was divided into upper gastrointestinal bleeding and no bleeding group, comparing the differences of HA, PT and PLT between groups. Results The PT, HA of hepatitis b patients with cirrhosis were increased and PLT decrease significantly than the chronic hepatitis B group and healthy group; HA, PT and abnormal PLT level in patients with cirrhosis B ＋ C were higher than the group of patients with liver cirrhosis A, the differences were statistically significant （P 〈 0.05）. It no obvious difference was found between the HA, the differ- ences of PT and PLT were statistically significant （P 〈 0.05） which upper gastrointestinal group compared with no bleeding. Conclusion PT, HA, and PLT in combination detection can response the liver damage degree and the illness weight, there has important reference value in diagnosis and treatment of cirrhosis of the liver.