不同类型心绞痛患者低密度脂蛋白及氧化型低密度脂蛋白的比较研究

Comparative study of low density lipoprotein and oxidized low density lipoprotein for patients with different types of angina pectoris

目的探讨低密度脂蛋白、氧化型低密度脂蛋白与冠状动脉心脏病之间的关系。方法冠状动脉痉挛(CAS)患者及稳定性心绞痛(SAP)患者共86例,40例正常体检患者,检测三组的各项血脂水平并进行对比分析。结果 CAS组和SAP组的LDL-C平均值均高于正常人群,弥漫性痉挛组、节段性痉挛组、单支病变组、多支病变组LDLC含量也高于正常人群,差异均有统计学意义(P<0.05)。SAP组、单支病变组、多支病变组的平均OX-LDL含量均高于CAS组及正常人群。CAS组和SAP组的TC、HDL-C与正常人群比较差异无统计学意义(P<0.05)。结论氧化型低密度脂蛋白不仅与冠脉粥样硬化的发生有关,而且其在血浆中的含量有可能与动脉粥样硬化的病变程度相关,因此比低密度脂蛋白与冠心病的联系更加紧密,是此类研究的新靶点。

Objective To explore the relationship between low density lipoprotein, oxidized lowdensity lipoprotein and coronary heart disease. Methods A total of 86 patients with coronary artery spasm （CAS） and stable angina pectoris （SAP）,40 cases of normal healthy people were arranged in three groups. Detected and compared the serum lipid levels. Results LDL-C of CAS group and SAP group were higher than the normal population. LDL-C of diffuse spasm group, segmental spasm group, single vessel disease group, multi branch lesion group were also higher than that in normal group, the difference had statistical significance （P 〈0.05）. ox-LDL content of SAP group, single vessel disease group, multi branch lesion group were higher than the CAS group and the normal group. TC, HDL-C of CAS group, SAP group and normal people were no difference （P 〈0.05）. Conclusion The ox-LDL is not only related with the occur- rence of coronary atherosclerosis lesions, and its content in plasma may be associated with atherosclerosis, and therefore low density lipoprotein and coronary heart disease are more closely linked, it is a new target of such research.