胰激肽原酶联合甲钴胺治疗糖尿病周围神经病变的临床研究

A clinical study of pancreatic kininogenase combined mecobalamin in treatment of diabetic peripheral neuropathy

目的观察胰激肽原酶片联合甲钴胺片治疗糖尿病周围神经病变(DPN)的临床疗效。方法 150例门诊DPN患者随机分为治疗组(n=75)和对照组(n=75)。治疗组用胰激肽原酶片联合甲钴胺片治疗,对照组使用复方丹参片联合腺苷钴胺片治疗,两组疗程均为30 d。结果从症状缓解、腱反射和神经传导速度测定改善情况三个方面比较,治疗组的疗效明显优于对照组。组间比较,差异有统计学意义(P<0.05)。结论胰激肽原酶片联合甲钴胺片治疗DPN疗效显著,值得临床广泛应用。

Objective To observe the clinical effects of pancreatic kiniogenase tablets combined with mecobalamin tablets in treatment of diabetic peripheral neuropathy （DPN）. Methods One hundred and fifty cases of outpatients with DPN were randomly divided into two groups： the treatment group （75 cases） and the control group （75 cases）. The treat- ment group with pancreatic kininogenase tablets and mecobalamin tablets treatment, minewhile,the control group using compound salvia tablets combined cobamamide tablets treatment, the period of treatment was 30 days. Results The re- mission of symptoms, tendinous reflex examination and nerve conduction velocity had been measured by comparing the three aspects, the efficacy of the treatment group was significantly better than the control group. Comparison between the two groups, the difference was statistically significant （P 〈 0.05）. Conclusion The efficacy of pancreatic kinino- genase tablets and mecobalamin tablets in treatment of DPN is significant, it is worthy of application.