亚临床甲减合并TPOAb阴性的孕妇后代出生情况研究

The study on obstetrical outcomes of subclinical hypothyroidism puerpera with TPOAb(-)

目的 研究亚临床甲状腺功能减退症合并甲状腺过氧化物酶抗体（thyroid peroxidase antibody,TPOAb）阴性的孕妇在治疗后其后代的出生情况.方法 选择2012年6月～2013年6月间妊娠中期筛查结果为亚临床甲状腺功能减退症伴TPOAb为阴性的45例孕妇进行研究,将其分成两组,其中用左旋甲状腺治疗者为研究组,其余不治疗的孕妇为对照组.对比分析两组孕妇的后代在身长、体重、头围、出生1min Apgar评分、出生缺陷率方面的差异.结果 两组孕妇的基本情况：年龄、怀孕次数、游离甲状腺素（Free thyroxine,FT4）、促甲状腺激素（Thyroid stimulating hormone,TSH）水平不具有统计学意义（P＞0.05）,研究组孕妇后代的身长、出生1 min Apgar评分、出生缺陷率与对照组孕妇后代的组间差异不具有统计学意义（P＞0.05）,但是研究组孕妇后代体重、头围均高于对照组孕妇后代,差异均具有统计学意义（P＜0.05）.结论 妊娠中期孕妇亚临床甲状腺功能减退症,即使伴TPOAb为阴性者,在经过左旋甲状腺治疗后,能够使新生儿的体重、头围得到增长,故应在孕期就要开始治疗.

Objective To investigate the obstetrical outcomes of subclinical hypothyroidism puerpera with TPOAb （-）. Methods In the present study, 45 women subclinical hypothyroidism puerpera with TPOAb （-） from Jun 2012 to Jun 2013 were divided into objective group and control group. The left-handed thyroid treatment was used in the objective group only. The height, weight, mental development index and psychomotor development index of preschools between two groups were compared. Results There was no significant differences of indicters including age, number of pregnan- cies, height, weight, FT4 and TSH levels of breastfeeding and duration of breastfeeding were found between of two group （P 〉0.05）. There was no significant different in rates of birth defects between two group （P 〉0.05）. But we found that height, weight, Apgar score in control group were higher than those in experimental group （P 〈0.05）. Conclusion It would get a satisfactory effect to use left-handed thyroid treatment among the subclinical hypothyroidism puerpera with TPOAb（-）, with better obstetrical outcomes.