睡眠呼吸暂停低通气综合征患者间歇性缺氧状态与非酒精性脂肪性肝病关系的研究

Study on the relationship between intermittent hypoxia of sleep apnea hypopnea syndrome patients and nonalcoholic fatty liver disease

目的研究睡眠呼吸暂停低通气综合征（sleep apnea—hypopnea syndrome，SAHS）患者慢性间歇性缺氧（chronic intermittent hypoxia，CIH）状态与非酒精性脂肪性肝病（Non alcoholic fatty liver，NAFL）的关系。方法选取深圳市第一人民医院2011年7月～2013年7月收治的60例OSAHS患者作为观察对象。所有患者均实施腹部B超以及血液检查。根据血氧饱和度（blood oxygen saturation，SpO2）分成轻度缺氧组、中度缺氧组和重度缺氧组。比较3组患者各项指标以及NAFL发病情况。结果重度缺氧组FBG、GT均明显高于轻度缺氧组以及中度缺氧组，重度缺氧组HDL明显低于轻度缺氧组。重度缺氧组GPT明显高于轻度缺氧组，重度缺氧组NAFL总发病率较中度缺氧组及轻度缺氧组明显更高，差异均具有统计学意义（P均〈0．05）。结论OSAHS的CIH状态与NAFL的发病密切相关，CIH程度越高，NAFL发病率亦越高。

Objective To study the relationship between chronic intermittent hypoxia of sleep apnea hypopnea syn- drome, SAHS） patients （CIH） and nonalcoholic fatty liver disease （non- alcoholic fatty liver, NAFL）. Methods Sixty OSAHS patients in our hospital from July 2011 to July 2013 were selected as the observation objects. All patients un- derwent abdominal B ultrasound and blood test. According to the degree of blood oxygen saturation （blood oxygen sat- uration, SpO2）, the cases were divided into mild hypoxia group, moderate hypoxia group and severe hypoxia group. The indexes and NAFL incidence were compared in three groups.Results FBG and GT of severe hypoxia group were significantly higher than those in mild hypoxia group and moderate hypoxia group, severe hypoxia group was signifi- cantly lower than that in mild hypoxia group of HDL level, GPT level in severe hypoxia group was significantly higher than that in mild hypoxia group, NAFL total incidence in moderate hypoxia group and mild hypoxia group was signifi- cantly lower than sever hypoxia group, the differences were statistically significant （P〈0.05）. Conclusion CIH state of OSAHS is closely associated with the pathogenesis of NAFL,the CIH level is higher, the incidence of NAFL is also higher.