小剂量阿司匹林与乳果糖联合治疗轻微型肝性脑病的临床研究

Research of low-dose aspirin combined with lactulose in the treatment of minimal hepatic encephalopathy

目的：探讨小剂量阿司匹林治疗轻微型肝性脑病的临床疗效。方法将符合诊断标准的肝硬化患者40例随机分为对照组（乳果糖15~60 ml/d）和联合组（阿司匹林25~75 mg/d＋乳果糖15~60 ml/d），各20例，比较两组心理测量评分变化、血氨水平、肝功能及 Child-pugh 评分。结果对照组和联合组总有效率分别为30.4%和55.6%，两组比较差异有统计学意义（P〈0.05）。与对照组相比，联合治疗组患者的丙氨酸转氨酶、天冬氨酸转氨酶、总胆红素和血氨水平变化比较差异无统计学意义（P〉0.05）。结论小剂量阿司匹林与乳果糖联用治疗轻微型肝性脑病疗效好，优于单用乳果糖。

Objective To explore the clinical efficacy of low-dose aspirin in the treatment of mild hepatic encephalopathy.Methods To divide 40 cirrhotic patients met the diagnostic criteria into control group（lactulose 15~60 ml/d）and the combined group（aspirin 25~75 mg/d ＋lactulose 15~60 ml/d） randomly, each were 20 cases. Compared the psychometrics core changes, blood ammonia levels,liver function and Child-pugh score.Results In the control group and the combined treatment group, the total effective rate was 30.4% and 55.6%, respectively. There were significant differences（P〈0.05）. Compared with the control group, patients treated with combined alacontrol nine aminotransferase, aspartate aminotransferase, total bilirubin andammonia levels had no significant difference（P＆gt;0.05）.Conclusion Low-dose aspirin with lactulose on patients with minimal hepatic encephalopathy has good effect, better than single lactulose.