腔隙性脑梗死患者中高同型半胱氨酸水平与认知功能障碍的研究

Study of the relationship between high homocysteine and cognitive impairment in patients with lacunar cerebral infarction

目的探讨血浆高同型半胱氨酸(HCY)水平是否与血管性认知功能障碍有关。方法以合肥市第二人民医院神经内科162例明确诊断的腔隙性脑梗死患者为研究对象,将入组患者血浆的HCY水平划分为高HCY(82例)和正常HCY(对照组,80例)两组,并通过对这两组患者进行多维度的神经心理学成套量表测查,来评估其认知功能。组间比较采用t检验。结果与对照组相比,高HCY组患者在空间工作记忆(N-back)和执行功能(Stroop试验)方面成绩差异有统计学意义(t=8.995～64.305,P均<0.05),而在长时记忆中的自由回忆任务中(AVLT)的成绩差异无统计学意义(P均>0.05)。结论血浆高HCY水平可能与脑梗死患者的认知功能障碍有关,主要表现为对其工作记忆以及执行功能的影响突出,而对其长时记忆障碍的影响并不显著。

Objective To investigate the relationship between high level plasma homocysteine （HCY） and vascular cognitive impairment （VCI）. Methods One hundred and sixty-two patients with lacunar infarction were from the neurology department of the second hospital in Hefei ,which were divided into two groups, one was high HCY group （82 cases）, the other was of normal level group （80 eases）. A battery of neurophysigical scales were used to evaluate their cognitive funetion. The differences between the two groups were compared by using t test. Results Compared with the normal controls, although the high HCY groups had been impaired in both working memory and Stroop test （ t = 8. 995-64. 305, all P 〈 0. 05 ）, they had not been impaired in AVLT（ all P 〉 0.05 ）. Conclusion It is possible that high level of plasma HCY may be related to vascular cognitive impairment, which have a main affection on working memory and Stroop test, but have rarely effection on long-term memory.