中药益肾活血序贯疗法改善卵巢功能衰退相关指标的研究

Research on Traditional Chinese Medicine Yishenhuoxue Sequential Therapy Improving Related Indicators of Ovarian Function Decline

目的：明确中药益肾活血序贯疗法改善卵巢功能衰退相关指标疗效。方法：选取我院及江西省妇幼保健院2007年5月～2013年7月门诊及住院部就诊的卵巢功能衰退患者共计80例。以数字表法随机分成观察组和对照组各40例。观察组采用益肾活血序贯疗法治疗，对照组采用西药含激素序贯疗法，2组3个月经周期为一个疗程。结果：治疗后临床总有效率，观察组为85．00％，对照组为62．50％。经Ridit分析，U=2．0241，P=0．0430〈0．05，具有统计学意义；治疗组治疗后潮热汗出、情绪不稳定、失眠、心悸、阴道干涩、月经紊乱、记忆力下降及泌尿系统症状的评分均较治疗前有明显改善，且具有统计学意义（P〈0．05）；治疗后2组患者血清E：均较治疗前提高，FSH及LH均较治疗前降低，2组治疗前后组内比较差异具有统计学意义（P〈0．05）。观察组治疗后E2、FSH及LH水平与对照组比较无明显差异（P〉O．05）。意义：中药益肾活血序贯疗法较之传统常规中药治疗方法更有优势，规律性强，且可以缩短用药时间，患者更易于接受。因此，值得临床进一步研究和应用。

Objective To define traditional Chinese medicine Yishenhuoxue sequential therapy improving related indicators of ovarian function decline. Methods 80 ovarian failure patients treated in outpatient and inpatient departments of our hospital and Jiangxi Provin cial Maternal and Child Health Hospital from May 2007 to July 2013 were selected. They were randomly divided into observation group and control group by number table, each group with 40 patients. Observation group was treated with Yishenhuoxue sequential therapy, while control group was treated with western sequential therapy with hormones. Three menstrual cycles as a course of treatment in the two groups. Results The total efficiency of clinical treatment in the observation group was 85.00%, while it in the control group was 57.50%. By Ridit analysis, U = 2.3011, P = O. 0214 〈 O. 05, there was statistically significant. The score of hot flashes sweating, emotional instability, insomnia, palpitations, vaginal dryness, menstrual disorders, memory loss and urinary tract symptoms in the ob servation group were improved significantly than before the treatment （ P 〈 O. 05 ）, and there was statistically significant. In the two groups, serum E2 was improved, FSH and LH were lower than before the treatment （ P 〈 O. 05 ）, there was statistically significant. There was no significantly difference in the level of E2, FSH and LH （ P 〉 O. 05 ）, the difference was not statistically significant. Con clusion Compared to traditional Chinese medicine treatment methods, there was more advantages, stronger regularity, shorter treatment time and more easily accepted by patients in Chinese Yishenhuoxue conventional sequential therapy. So, it is worthy of further research and application.