抗凝治疗肾病型早发型重度子痫前期疗效评价

Effect evaluation of three type of anticoagulant treatment on nephrotic syndrome of early onset severe pre-eclampsia

目的观察不同抗凝治疗肾病型早发型重度子痫前期母体的影响。方法选取孕龄26～34周重度子痫前期患者123例，其中。肾病型患者81例，A组27例应用硫酸镁加低分子肝素钙，B组28例应用硫酸镁加丹参，C组26例应用硫酸镁加低分子肝素钙和丹参。比较三组平均动脉压、24h尿蛋白定量、血脂、并发症的差异。结果三组观察指标治疗前后对比差异有统计学意义。治疗后C组平均动脉压，24h尿蛋白，血脂TG、TC、LDL均下降，与A、B组相比，差异有统计学意义（P〈0．05）。A、C两组HDL增加，两组间差异有统计学意义（P〈0．05）；并发症降低。结论抗凝治疗肾病型早发型重度子痫前期能够有效改善母体生理状况，降低并发症。低分子肝素钙联合丹参治疗效果更佳。

Objective To analyze the maternal effect of low molecular heparin calcium and salvia mihiorrhiza on ne- phrotic syndrome of early onset severe pre - eelampsia. Methods Eighty - one of patients with nephrotic syndrome of early onset severe pre - eclampsia were randomly divided into three groups . LMWHC was used in A group, Salvia milti- orrhiza was used in B group, and LMWHC with Salvia miltiorrhiza were used in C group. Index reflecting such as , MAP, blood fat, 24 - hour urinary protein quantitative, and complications were measured in three groups. Results Before and after treatment , there are significant difference of observation indexes between the three group. In C group, MAP, 24 - hour urinary protein quantitative, TG, TC, LDL were all decreased and HDL were increased. There are significant differ- ence between the three group P 〈 0. 05. Complications reduced. Conclusion The anticoagulant treatment on nephrotic syndrome of early onset severe pre - eclampsia can effectively improve maternal physiology, reduce the complications. The treatment effect of LMWHC with Salvia is better than separate application.