趋化因子CXCL12及其受体CXCR4在大疱性类天疱疮皮损中的表达

Expressions of CXCL12 and CXCR4 in Skin Lesions of Patients with Bullous Pemphigoid

目的研究趋化因子CXCL12及其受体CXCR4在大疱性类天疱疮(BP)皮损中的表达。方法采用免疫组织化学法检测及图像观察分析51例BP皮损和49例正常对照石蜡切片中CXCL12和CXCR4的表达,并根据细胞质中不同程度的染色判定阳性等级。结果 CXCL12和CXCR4在BP皮损表皮均有较强的阳性表达(阳性率分别为96.1%和94.1%),而在正常皮肤中不表达或弱阳性表达(阳性率分别为40.8%和73.5%),CXCL12和CXCR4表达阳性率的差异均有统计学意义(P<0.05)。结论 CXCL12和CXCR4在BP皮损中呈阳性表达,提示二者可能在BP的发病机制中起一定的作用。

Objective To study the expressions of chemokine CXCL12 and its receptor CXCR4 in the skin lesions of bullous pemphigoid. Methods The expressions of CXCL12 and CXCR4 were detected in the skin lesions of 51 patients with bullous pemphigoid and 49 normal controls by immunohistochemical staining and image analysis. Results CXCL12 and CXCR4 were strongly expressed in the lesional epidermis of bullous pemphigoid group （96.1% and 94.1% positive, respectively ）, but weakly or negatively expressed in normal control group （40.8% and 73.5% posi- tive, respectively）. The differences between the two groups were significant （P 〈 0.05 ）. Conclusion The increased expression of CXCL12 and CX- CR4 in the lesions of bullous pemphigoid indicates that they might play an important role in the pathogenesis of bullous pemphigoid.