活络通脑片对脑卒中的预防作用研究(Ⅰ)

Study on Prevention Effect of Huoluotongnao Tablet on Stroke(Ⅰ)

目的:研究活络通脑片对脑卒中的预防作用。方法:分别考察活络通脑片对大鼠动静脉旁路血栓形成、大鼠血小板聚集及高血压合并高血脂大鼠脑动脉硬化模型的影响。结果:活络通脑片中、高剂量能显著抑制大鼠动静脉旁路血栓的形成及大鼠全血血小板聚集度(P<0.05),抑制率分别为17.71%、22.69%和20.34%、24.43%;活络通脑片预防给药能显著抑制动静脉血栓的形成;活络通脑片各剂量均能显著降低高血压合并高血脂致脑动脉硬化模型大鼠CHOz水平,高剂量能显著降低TGz、LDL-C水平,中剂量有一定的降血压作用,中、高剂量能降低全血低切(ηbL)、ηP、ηr(B/P),高剂量能降低中切(ηbM)、红细胞聚集指数(AI)、卡松屈服应力(CY),对脑血管病变也有较好的改善作用,可显著抑制脑血管动脉硬化症状的形成。活络通脑片对大鼠血脂、血压和血液流变学的作用呈一定的量效关系,起效剂量为中剂量。结论:活络通脑片中剂量(生药1.28 g/kg)为起效剂量,对脑卒中具有一定的预防作用。

Objective： To study the prevention effect of Huoluotongnao tablet on stroke. Methods： Thrombosis on arteriovenous shunt rats model,platelet aggregation and hypertension combined high cholesterol rats model were used. Results： Huoluotongnao tablet high and low dosage could inhibit the formation of arteriovenous thrombosis and platelet aggregation significantly,the inhibition rate was 17. 71%,22. 69%,20. 34% and 24. 43%,respectively. Pretreatment of Huoluotongnao tablet could inhibit the formation of arteriovenous thrombosis significantly; The levels of CHOz in all treatment groups of hypertension combined high cholesterol rats model were decreased significantly,the levels of TGz and LDL-C were decreased in the high dosage group,the blood pressure was decreased in the middle dosage group. ηbL,ηP and ηr（ B / P） were decreased in the middle and high dosage groups. ηbM,AI and CY were decreased in the middle and high dosage groups. Huoluotongnao tablet had effect on blood lipid,blood pressure and hemorheology and in a dose-dependence manner. Its minimal effecting dose was the middle dose. Conclusion： Huoluotongnao tablet＇s minimal effecting dose is 1. 28 g / kg（ crude drug） and has certain prevention effect on stroke.