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白蛋白结合型紫杉醇联合卡铂治疗晚期非小细胞肺癌的近期疗效及安全性观察 被引量:4

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摘要 目的观察注射用白蛋白结合型紫杉醇联合卡铂治疗晚期非小细胞肺癌的近期疗效及安全性。方法将25例晚期非小细胞肺癌患者给予注射用白蛋白结合型紫杉醇联合卡铂治疗,观察患者的近期疗效和不良反应。结果 CR 1例,PR 10例,SD 8例,PD 6例,总有效率(CR+PR)为45%。结论白蛋白结合型紫杉醇联合卡铂治疗晚期非小细胞肺癌疗效较好,不良反应可以耐受。
作者 吕巧妹
出处 《中国医药指南》 2014年第11期151-152,共2页 Guide of China Medicine
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参考文献9

  • 1孙燕 周际昌.临床肿瘤内科手册[M].北京:人民卫生出版社,2003.586-591.
  • 2Ricc I,Antonuzzo A,Calli L,et al.Gemcitabine monotherapy in elderly patients with advanced non-small lung cancer a multi- center phase Ⅱ study[J].Ltmg Cancer,2000,27(2):75-80.
  • 3滕小玉,管忠震,姚志文,刘冬耕,周宁宁,罗汉钰,Michael Hawkins,Patrick Soon-Shiong.晚期实体癌患者对不含聚氧乙烯蓖麻油注射用紫杉醇白蛋白纳米粒悬浮液的临床耐受性研究[J].癌症,2004,23(z1):1431-1436. 被引量:39
  • 4Schnitxcr JE,Oh P.Antibodies to SPARC inhibit albumin binding toSPARC,gp60,and microvascular endothelium[J].Am J Physiol, 1992,263(6 Pt 2): H1872-H1879.
  • 5Rempel SA,Ge S,Gutierrez JA.SPARC: A potential diagnostic markerof invasive meningiomas[J].Clin Cancer Res,1999,5(2): 237-242.
  • 6Porter PL,Sage EH,Lame TF, et al.Distribution of SPARC in nor mal and neoplastic human tissue[J].J Histochem Cytochem,1995, 43(8):79-88.
  • 7Desai N,Trieu V, Yao ZW, et al.Increased antitumor activity, in tratumor paclitaxel concentrations,and endothelial cell transport ofcremophor- free,albumin-bound paclitaxel,ABI-007,compared withcremophor-based paclitaxel[J].Clin Cancer Res,2006,12(4): 1317.
  • 8John TA,Vogel SM,Tiruppathi C,et al.Quantitative analysis of al bumin uptake and transport in the rat microvessel endothelialm- onolayer[J].Am J Physiol Lung Cell Mol Physiol,2003,284(1): L187-195.
  • 9Porter PL,Sage EH,Lane TF, et al.Distribution of SPARC in norm- aland neoplastic human tissue[J].J Histochem Cytochem, 1995,43 (8):791-800.

二级参考文献22

  • 1[1]Taxol(R) (paclitaxel) Injection [package insert]. Princeton, New Jersey: Bristol-Myers Squibb Co; March 2003
  • 2[2]Lorenz W, Reimann HJ, Schmal A, et al. Histamine release in dogs by Cremophor EL and its derivatives: Oxethylated oleic acid is the most effective constituent [ J]. Agents Actions, 1977, 7 ( 1 ): 63 -67.
  • 3[3]Gelderblom H, Verweij J, Nooter K, et al. Cremophor EL: The drawbacks and advantages of vehicle selection for drug formulation [J]. Eur J Cancer, 2001, 37(13): 1590 - 1598.
  • 4[4]Rowinsky EK, Donehower RC. Paclitaxel (taxol) [J]. N Engl J Med, 1995, 332(15): 1004 - 1014.
  • 5[5]Szebeni J, Muggia FM, Alving CR. Complement activation by Cremophor EL as a possible contributor to hypersensitivity to Paclitaxel: an in vitro study [J]. J Natl Cancer Inst, 1998, 90(4):300 - 305.
  • 6[6]ten Tije AJ, Verweij J, Loos WJ, et al. Pharmacological effects of formulation vehicles: Implications for cancer chemotherapy [J] .Clin Pharmacokinet, 2003, 42 (7): 665 - 685.
  • 7[7]van Zuylen L, Karlsson MO, Verweij J, et al. Pharmacokinetic modeling of paclitaxel encapsulation in Cremophor EL micelles [J]. Cancer Chemother Pharmacol, 2001, 47(4): 309 - 318.
  • 8[8]Sparreboom A, van Zuylen L, Brouwer E, et al. Cremophor EL-mediated alteration of paclitaxel distribution in human blood:clinical pharmacokinetic implications [J] . Cancer Res, 1999, 59(7): 1454 - 1457.
  • 9[9]Ibrahim NK, Desai N, Legha S, et al. Phase Ⅰ and pharmacokinetic study of ABI-007, a Cremophor-free proteinstabilized. nanoparticle formulation of paclitaxel [J]. Clin Cancer Res, 2002, 8(5): 1038 - 1044.
  • 10[10]Paridaens R, Biganzoli L, Bruning P, et al. Paclitaxel versus doxorubicin as first-line single-agent chemotherapy for metastatic breast cancer: a European Organization for Research and Treatment of Cancer Randomized Study with cross-over [J]. J Clin Oncol, 2000, 18(4): 724 - 733.

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