摘要
目的探讨胃肠道恶性肿瘤组织中磷脂酰肌醇3-激酶(PI3K)、蛋白激酶B(Akt)和细胞外信号调节蛋白激酶l/2(ERKl/2)的表达及意义。方法回顾性分析2011年8月至2013年6月间收治的50例胃肠道恶性肿瘤组织标本的临床资料。结果胃肠道恶性肿瘤组织中PI3K、Akt和ERKl/2的阳性表达率和免疫组化评分均明显高于癌旁组织,差异有统计学意义(P<0.05);患者年龄、病理类型、淋巴结转移、病理分期和远处转移情况与PI3K、Akt和ERKl/2的表达无显著相关(P>0.05)。结论胃肠道恶性肿瘤组织中PI3K、Akt和ERKl/2呈高表达,但与临床病理无关,可能参与肿瘤发生发展的早期事件。
Objective To investigate the significance of PI3K,Akt,ERK1/2 expression in gastroin- testinal malignant tumor tissues. Methods 50 cases of gastric bowel malignant tumor tissue samples in our hospital from 2011 August to 2013 June were retrospectively analyzed. Results PI3K,Akt,ERK1/2 posi- tive expression rates and immunohistochemical score in gastrointestinal malignant tumor tissues were signifi- cantly higher than those in noncancerous tissue （P 〈 0.05 ） ; PI3 K, Akt, ERK1/2 expression in gastrointesti- nal malignant tumors were not significantly correlated with patient＇s age,pathological types,lymph node me- tastasis, distant metastasis and pathological staging（P 〉 0. 05）. Conclusion PI3K, Akt, ERK1/2 have high expression in gastrointestinal malignant tumor tissues, but has nothing to do with clinical pathology, and may- be involved in the early events of the occurance and development of tumor.
出处
《中国肿瘤临床与康复》
2014年第4期389-391,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
