麻醉深度指数反馈调控在老年肿瘤患者靶控输注丙泊酚麻醉中的临床研究

The clinical application of anesthesia depth index( CSI) feedback control in target controlled infusion of propofol for elderly cancer patients

目的探讨麻醉深度指数(CSI)反馈调控在老年肿瘤患者靶控输注丙泊酚麻醉中的临床应用及价值。方法选取132例胃癌和直肠癌根治术的老年肿瘤患者(≥65岁),随机分为CSI反馈靶控输注麻醉的试验组(66例)和靶控输注麻醉的对照组(66例),比较分析两组患者的麻醉效果。结果两组患者的术中平均动脉压(MAP)均有明显变化,对照组患者T3、T4和T5的MAP值低于试验组(P<0.05)。两组患者术中心率(HR)和心率变异(HRV)均存在波动,其中对照组患者T3和T5的HRV较试验组明显下降(P<0.05)。试验组患者的CSI值波动和丙泊酚总用量均小于对照组(P<0.05)。结论采用CSI反馈调控可以提高老年肿瘤患者靶控输注丙泊酚麻醉的安全性,有利于指导合理用药,具有较高的应用价值。

Objective To study the clinical effects of anesthesia depth index （CSI） feedback con- trol for elderly patients with tumor target controlled infusion （TCI） of propofol. Methods 132 patients with gastric and colorectal cancer in elderly patients were randomly divided into the control group （ treated with TCI） and the observation group （treated with feedback TCI）. The American Society of Anesthesiologists （ASA） level for all of the patients was Ⅰ-Ⅱ , and the narcotic effect was compared between the two groups. Results The average mean arterial pressure （MAP） were significantly changed, and the value in the control group at T3, T4 and T5 was less than the ovservation group （P 〈0. 05）. Tile heart rate variabil- ily （HRV） at T3 and T5 in the control group was also less than the observation group（P 〈0. 05）. The CSI value and total dosage of propofol in the observation group were less than the control group （ P 〈 0. 05 ）. Conclusion The CSI feedback regulation in TCI propofol for elderly cancer patients is safe and effective, which is heloful to ~uide the rational use of drugs and imnrove the safety of anesthesia.