放射治疗联合康莱特治疗鼻咽癌的疗效观察

Efficacy analysis of radiotherapy combined with Kanglaite in patients with nasopharyngeal carcinoma

目的探讨放射治疗联合康莱特治疗鼻咽癌的疗效。方法回顾性分析2007年1月至2009年1月收治的接受放射治疗的86例老年鼻咽癌患者的临床资料,依据患者的治疗方式随机分为观察组(放射治疗+康莱特,41例)和对照组(放射治疗,45例),比较两组患者的短期临床疗效、不良反应、放射治疗后血液指标的变化和治疗后3年生存率。结果观察组患者的治疗有效率显著高于对照组患者,差异有统计学意义(P<0.05)。观察组患者的不良反应发生率显著低于对照组患者,差异有统计学意义(P<0.05)。观察组患者的治疗后3年生存率显著高于对照组患者,差异有统计学意义(P<0.05)。放射治疗后,观察组患者的白细胞、血红蛋白、白蛋白和CD+4/CD+8比值均显著高于对照组患者。结论老年鼻咽癌患者放射治疗合并康莱特可以降低放射治疗的不良反应发生率,提高治疗有效率和治疗后3年的生存率。

Objective To evaluate efficacy analysis of radiotherapy combined with Kanglaite in pa- tients with nasopharyngeal carcinoma. Methods Clinical data of 86 patients with nasopharyngeal carcinoma received radiotherapy treatment was prospective analyzed from January 2007 to January 2009. Patients were randomly divided into two groups according to treatment method： observation group （radiotherapy ＋ kang- laite, 41 cases） and control group （radiotherapy, 45 cases）. The short term clinical efficacy, toxicity/side effect, changes of blood indexes and survival rate of 3-year after treatment were compared between the two groups. Results The efficacy rate and survival rate of 3-year after treatment of observation group were sig- nificantly higher than that of control group （ P 〈 0. 05 ）. However, the toxicity/side effects of observation group were significantly lower than that of control group （P 〈0. 05）. The levels of Hb, WBC, CD4＋/EDs ratio and albumin of observation group were higher than that of control group after radiotherapy. Conclusion Radiotherapy combined with Kang｜aite can reduce the toxic/side effects, improve the efficacy rate and 3- year survival rate in patients with nasopharyngeal carcinoma.