AGR2与肿瘤关系研究进展

Anterior gradient 2 in cancer developmen

前梯度基因2(Anterior gradient2 AGR2)是一种新型癌基因,研究表明AGR2的表达与哮喘、炎症性肠病、肿瘤的发生转移预后及药物抵抗有关。过度表达的AGR2蛋白参与肿瘤信号途径,促进肿瘤细胞的存活、增殖和转移的发生,如乳腺癌、食管癌、胃肠癌、胰腺癌、前列腺癌、卵巢癌等;相反AGR2基因表达缺失会导致细胞生存能力减弱、细胞周期进展,进而导致细胞凋亡。本文就AGR与多种肿瘤的研究进展做一综述,进一步探讨AGR2基因作为潜在的药物治疗靶点及早期诊断预后的新型肿瘤标记物在临床的应用价值。

Anterior gradient2 as a novel oncogen has been shown using a range of expression to be involved in asthma,inflammatory bowel disease,cell transformation,cancer drug resistance and metastatic growth. AGR2 protein is highly over- expressed in human cancer and involved in pro- oncogenic signal,regulate human cancer cells survival,proliferation and metastasis,as breast cancer,esophageal cancer,gastrointestinal cancer,pancreatic cancer. Contrarily,AGR2 gene deletion reduce cell survival cycle progression,apoptosis. This paper will review the cases of AGR2 expression in human cancer,evaluated the clinical application of its potential role as target for drug therapy and early diagnosis of novel prognostic tumor maker.