血清神经元特异性烯醇化酶在新生儿缺氧缺血性脑病诊断中的临床意义

Clinical significance of serum neuronspecific enolase in diagnosis of neonatal hypoxic-ischemic encephalopathy

目的：探讨、分析、检测血清神经元特异性烯醇化酶（NSE）水平对于诊断新生儿缺氧缺血性脑病（HIE）的临床意义。方法：选取2013年1～12月在本院收治的缺氧缺血性脑病新生儿50例（均为足月新生儿），轻度23例，中度18例，重度9例，为病例组；同期选取正常足月新生儿25例，为对照组，于新生儿出生的第1天、3天和7天采集血液样本后，采取放射免疫法测定NSE值。结果：在第1、3天NSE水平检测结果为病例组高于对照组，差异有统计学意义（P〈0．05）；经7天治疗后，轻度患儿NSE水平大部分恢复正常。结论：新生儿血清中NSE水平可作为一灵敏指标用于早期诊断新生儿缺氧缺血性脑病。

Objective： To explore and analyze the clinical significance of detecting serum neuronspecific enolase （NSE） level in diagnosis of neonatal hypoxic -ischemic encephalopathy （HIE） . Methods： Fifty full -term neonates with HIE treated in the hospital from January to December in 2013 were selected as case group, including 23 neonates with mild HIE, 18 neonates with moderate HIE and 9 neo- nates with severe HIE ; 25 normal full - term neonates during the same period were selected as control group ; the blood samples of the neo- nates in the two groups were collected on the first day, the third day and the seventh day after birth, then NSE levels were detected by radio- immunoassay. Results： NSE levels on the first day and the third day after birth in case group were statistically significantly higher than those in control group （P 〈 0. 05 ） ; after treatment for 7 days, NSE level of partial neonates with mild HIE returned to normal. Conclusion： Neo- natal NSE level is a sensitive indicator which can be used in early diagnosis of neonatal HIE.