海绵共附生真菌多样性及其次级代谢产物的研究进展

Studies on Diversity of Sponges-associated Fungi and Their Secondary Metabolites

海绵由于其独特的生理结构、进食方式使其体内部聚集了大量的微生物,这些微生物产生了多种结构新颖的生物活性物质,因此海绵及其共附生微生物的研究成为了海洋药物研发的热点。就海绵中共附生真菌的分布情况,新技术的应用及其生物次级代谢产物的生物活性展开综述。

Because of the unique physiological structure and digest system, marine sponges enrich large numbers of microorganisms. Lots of novel bioactive compounds were isolated and identified from sponges-associated fungi, which is highlight in marine drug discovery. The development on the distribution of fungi, the application of new technique, novel bioactive secondary metabolites and biological activities were reviewed.