提高蛋白多肽口服生物利用度的方法

Approaches for Enhancing Oral Bioavailability of Peptides and Proteins

综述了常用的提高蛋白多肽生物利用度的策略,包括化学修饰、吸收促进剂、粘膜粘附系统、脂质体和纳微球等,系统分析了各种策略的研究现状及优缺点,重点分析了纳微球的研究现状.指出在纳微球的基础上对影响药物释放和吸收的各方面因素进行系统化、个性化设计,有望设计出可应用于临床的蛋白多肽口服给药系统.

The approaches for enhancing oral bioavailability of biomacromolecules, such as peptides and proteins, including chemical modification, absorption enhancers, mucoadhesive systems, liposomes and nano-microparticles are comprehensively reviewed, and the status of these approaches and their relative merits analyzed, focusing on the status of nano-microparticles. Finally, it is pointed out that on the basis of nano-microparticles, analyzing and designing all aspects of drug release and absorption systematically and personally, oral drug delivery system ofpeptides and proteins for clinical applications is expected to construct.