摘要
One new 6,7-seco-ent-kaurane diterpenoid, sculponin T (1), was isolated from the aerial parts of lsodon sculponeatus, along with four known analogs, sculponeatin J (2), sculponeatin K (3), sculponeatin C (4), and sculponeatin Q (5). Their structures were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. Significant cytotoxic activity was observed for compound 2 against five human tumor cell lines with IC50 values ranging from 1.8 μmol/L to 3.3 μmol/L, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC50 value of 3.3 μmol/L.
One new 6,7-seco-ent-kaurane diterpenoid, sculponin T (1), was isolated from the aerial parts of lsodon sculponeatus, along with four known analogs, sculponeatin J (2), sculponeatin K (3), sculponeatin C (4), and sculponeatin Q (5). Their structures were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. Significant cytotoxic activity was observed for compound 2 against five human tumor cell lines with IC50 values ranging from 1.8 μmol/L to 3.3 μmol/L, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC50 value of 3.3 μmol/L.
基金
supported financially by the National Natural Science Foundation of China(Nos.21322204 and 81172939)
the NSFC-Joint Foundation of Yunnan Province(No.U1302223)
the Reservation-talent Project of Yunnan Province(No.2011CI043)
the West Light Foundation of the Chinese Academy of Sciences(Jian-Xin Pu)