摘要
本文对哒螨灵注射剂和口服剂应用白家兔进行了药物动力学试验 ,分别测定出哒螨灵注射剂和口服剂在白家兔体内吸收速率常数 (Ka) ,消除速率常数 (K) ,药物吸收一半时间 (T1 / 2 Ka) ,生物半衰期 (T1 / 2 ) ,药峰时间(Tp) ,曲线下面积 (AUC) ,生物利用度 (F) ,药峰浓度 (Cpk) ,表观容积 (V)分别为 0 .2 2 17h- 1 ,,0 .0 746 1h- 1 ,3.12 h,9.30 h,0 .96 ,30 0 .0 5μg· h/ m L ,5 8.5 5μg/ m L ,7.40 5 8h和 0 .2 86 3h- 1 ,0 .0 6 786 h- 1 ,2 .42 h,10 .2 1h,1.0 0 ,30 0 .35μg·h/ m L ,71.74μg/ m L ,6 .5
Pharmacokinetics experiments of Pyridaben injection dosage and oral dosage have been carried out in domestic white rabbits. Pharmacokinetics parameters were separately determined. The Absorption rate constant (Ka), Elimination rate contant(K), Drug absorption half time(T 1/2Ka ), Elimination half time (T 1/2k ), Bioavailbility (F), Area under curve (AUC), Blood peak value of concentration (Cp), and Time of peak value (Tp) are 0.2217h -1 , 0.07461 h -1 , 3.12h,9.30h,0.96,300.05μg·h/mL, 58.55 μg/mL,7.4058h and 0.2863 h -1 , 0.06786 h2.42h,10.21h,1.00,300.35μg·h/mL,71.74μg/mL, 6.591h.
出处
《中国兽医寄生虫病》
2001年第1期1-4,共4页
Chinese Journal of Veterinary Parasitology
关键词
哒螨灵
注射剂
口服剂
药物动力学参数
家兔
兽医药理学
Pyridaben
injection dosage
oral dosage
Pharmacokinetics parameters
Domestic rabbit