白介素-17、-23在结核性脑膜炎中的免疫致病机制探讨被引量：4

The Pathological Mechanism of Interleukin-17,-23 in Tubercular Meningitis Patients

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摘要目的:探讨白介素(IL)-17、-23在结核性脑膜炎(TBM)中的致病机制及其对TBM诊断和预后的意义。方法:用双抗体夹心法检测18例TBM患者(TBM组)血清及脑脊液(CSF)中IL-17、-23因子水平。并对IL-17、-23与TBM组CSF中各参数的相关性进行分析。结果:TBM组血清和CSF中IL-17水平分别为83.8±5.9和106.4±8.8;IL-23水平分别为103.1±7.1和172.8±8.3,与对照组比均有统计学意义(P<0.01)。且IL-17、-23升高水平与TBM组CSF中的WBC数量正相关。结论:IL-17、-23在TBM的免疫致病机制中起着重要作用。 Objective：To reveal the pathological mechanism and the prognostic value of interleukin-17,-23 in the tubercular meningitis（TBM）patients. Methods：Serum and CSF of 18 TBM patients were collected to detect IL-17,-23 with ELISA method. The relationship of IL-17,-23 changes with the parameters of CSF was analyzed by the pearson correlation. Results：IL-17,-23 levels in serum and CSF in the TBM group were 83.8±5.9 and 106.4±8.8,103.1±7.1 and 172.8±8.3, respectively. IL-17,-23 in the TBM group were higher than those the control group（P0.01）. IL-17,-23 had correlation with WBC numbers. Conclusion：IL-17,-23 may play important roles in pathological mechanism of TBM.

作者程碧珍杨礼林诗扬张俏忻蔡应木

机构地区汕头大学医学院第一附属医院检验科广州医科大学临床医学系

出处《汕头大学医学院学报》 2014年第1期33-34,37,共3页 Journal of Shantou University Medical College

基金广东省自然科学基金资助项目(S2012010009081)

关键词结核性脑膜炎白介素-17 白介素-23 tubercular meningitis interleukin-17 interleukin-23

分类号 R446.62 [医药卫生—诊断学]

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