血清转化生长因子-β_1在B细胞性急性淋巴细胞白血病的表达及其临床意义

Expression and Significance of Serum Transforming Growth Factor-β_1 in B-cell Acute Lymphoblastic Leukemia

目的:探讨血清转化生长因子(TGF)-β1在B细胞性急性淋巴细胞白血病(ALL)患者中的表达及其临床意义。方法:用ELISA法定量检测57名B细胞性ALL患者(20名初诊者(初诊组),15名骨髓复发者(骨髓复发组),7名骨髓外转移者(骨髓外转移组)及15名完全缓解者(完全缓解组))和10名健康志愿者(对照组)血清TGF-β1浓度。结果:与对照组比,血清TGF-β1浓度在初诊组中降低(P<0.05);在完全缓解组中升高;在骨髓复发或骨髓外转移组中均低(P<0.05);初诊、骨髓复发及骨髓外转移组间比均无统计学意义。与其他指标进行相关性分析表明,血清TGF-β1浓度与病人外周血白细胞数呈负相关(R=-0.344,P<0.01),与外周血红细胞计数(R=0.460,P<0.01)、血红蛋白浓度(R=0.439,P<0.01)和血小板计数(R=0.907,P<0.01)呈正相关,与年龄、性别等指标无相关性。结论:血清TGF-β1浓度可作为监测ALL患者病情转归的一项有价值的指标。

Objective：To investigate the expression and significance of serum transforming growth factor（TGF）-β1 in B-cell acute lymphoblastic leukemia（ALL）patients. Methods：The serum TGF-β1 levels were detected by ELISA in 57 adult B-cell ALL patients（20 newly diagnosed cases（newly diagnosed group）,15 recurrent cases（recurrent group）,7 bone marrow metastasis cases（bone marrow metastasis group）,15 completely remission cases（completely remission group））and 10 healthy individuals（control group）. Results：The serum TGF-β1 level in the newly diagnosed group was significantly lower than that in the control group（P〈0.05）. The TGF-β1 level in the complete remission group was increased. The TGF-β1levels in the recurrent and metastasis groups were lower（P〈0.05）. No significant differences were found among newly diagnosed,recurrent and metastasis groups. The serum TGF-β1 levels correlated negatively with the white blood counts in peripheral blood（R=-0.344,P0.01）,and positively with the red blood counts（R=0.460,P0.01）,hemoglobin（R=0.439, P〈0.01）and platelet,respectively. Conclusion：Serum TGF-β1 level can be regarded as a marker for monitoring the prognosis of B-cell ALL patients.