p28GANK在乙肝相关肝癌中表达意义

The expression and significance of p28GANK in patients with HBV-related hepatocellular carcinoma

目的研究p28GANK在乙肝相关性肝癌组织中表达的临床意义。方法收集乙肝相关的肝癌及对应癌旁组织,采用免疫组织化学检测p28GANK肝癌及其对应癌旁组织中表达差异;分析其在肝癌组织中表达水平与患者临床参数的相关性;分析其表达与HBV复制水平的相关性。结果免疫组化显示p28GANK在肝癌组织表达水平显著高于其对应癌旁组织(P<0.01)。p28GANK表达水平与患者TNM分期、侵袭转移及HBV-DNA复制水平显著相关(P<0.05),而与患者性别、年龄及血清AFP水平无关(P>0.05)。结论 p28GANK在HBV相关肝细胞癌中表达增强,可能参与HBV-DNA复制,是治疗HBV相关肝癌的重要生物靶点。

Obiective To investigate the expression and significance of p28GANK in patients with HBV-related hepatocellular carcinoma（HCC）.Mehtods A total of 60 patients with HBV-related HCC and matched non-tumor tissues were collected and the expression of p28GANK were determined by using immunohistochemical staining.Results Immunohistochemistry revealed that the expression of P28GANK in HCC was significantly increased compared with matched non-tumor tissues （P〈0.01）. Higher P2gGANK expression was correlated with advanced TNM staging, invasion and HBV-DNA replication （P〈0.05）, but not with age, gender and AFP levels（P〉0.05）. Conclusiogn P28GANK expression in HBV-related HCC was correlated with malignant progression and HBV replication, which might be a target for treatment of HBV-related HCC.