N-甲基乙酰胺合成工艺研究

Synthesis of N-Methylacetamide

以乙酸甲酯、一甲胺为原料合成N-甲基乙酰胺，在n（乙酸甲酯）∶n（一甲胺）=1∶1.10~1.15，助剂用量为原料乙酸甲酯的20%~30%（质量分数），反应温度120~125℃，反应时间3.5~4.0h；反应压力2.0~2.5MPa，催化剂加入量占乙酸甲酯原料量0.05%~0.07%的条件下，乙酸甲酯转化率≥95%，N-甲基乙酰胺选择性≥93%。

N-methylacetamide was prepared with methyl acetate, methylamine as raw materials. The process conditions and influence factors were studied. The results showed that when the molar ratio of methyl acetate to methylamine was 1.10~1.15, the auxiliary of methyl acetate accounted was 20%~30%of the raw materials, reaction temperature was 120~125℃, reaction time was 3.5~4.0 h, re-action pressure was 2.0~2.5MPa, the catalyst amount was 0.05%~0.07%of the methyl acetate, the conversion rate of methyl acetate was above 95%, the selectivity of N-methylacetamidee was 93%.