摘要
人表皮生长因子受体3(human epidermal growth factor receptor 3,HER3)是Ⅰ型跨膜酪氨酸激酶受体,在多种肿瘤中表达上调.此文就HER3的结构特征、HER3与肿瘤的关系以及抗HER3抗体的抗肿瘤作用进行简要综述.
Human epidermal growth factor receptor 3 ( HER3 ) is a type I transmembrane tyrosine kinase receptor. HER3 gene expression is up-regulated in a variety of tumors. This article briefly reviews the structural characteristics of HER3, the relationship between HER3 and tumorigenesis, and anti-tumor effect of antibody against HER3.
出处
《国际生物制品学杂志》
CAS
2014年第2期93-96,共4页
International Journal of Biologicals
关键词
受体
表皮生长因子
抗体
单克隆
肿瘤治疗方案
Receptor, epidermal growth factor
Antibodies, monoclonal
Antineoplastic protocols