前列腺IL-8、COX-2表达与组织增生伴炎症的相关性研究

Correlation between the level of IL-8, COX-2 in prostate and benign prostatic hyperplasia with prostatitis

目的：观察良性前列腺增生（BPH）合并前列腺炎症与前列腺液、前列腺组织中炎症因子白介素-8（IL-8）、环氧化酶-2（COX-2）水平的相关性。方法80例BPH拟行经尿道前列腺电切术（TURP）患者，根据术后病理学诊断分为单纯性增生组（30例）和增生伴炎症组（50例），两组均于术前进行前列腺液IL-8、COX-2含量测定，术后前列腺组织IL-8、COX-2含量测定，进行统计学分析。结果分别对前列腺液、前列腺组织中IL-8和COX-2 OD值进行组间比较，组间差异性具统计学意义（P＜0.01）；组内比较IL-8和COX-2在前列腺液及前列腺组织中的水平变化，趋势呈线性正相关（r＞0.5），其中，IL-8表达水平在两种标本中呈高度相关（r＞0.08）。结论前列腺液中IL-8、COX-2水平能间接反映前列腺组织中IL-8、COX-2水平，通过检测患者前列腺液中IL-8、COX-2水平可以初步判定BPH患者是否合并有前列腺组织学炎症。

Objective To investigate the relationship between benign prostatic hyperplasia （BPH） with inflammation and level of interleukin-8 （IL-8） and cyclooxygenase-2 （COX-2） in prostate tissue and expressed prostatic secretions. Methods A total of 80 BPH patients who would be treated by transurethral resection of the prostate （TURP） were divided into simple hyperplasia group （30 patients） and huperplasia with inflammation group （50 patients） identified by postoperative pathologic diagnosis. Preoperative levels of IL-8 and COX-2 in expressed prostatic secretions and postoperative levels of IL-8 and COX-2 in prostate tissue were detected and comparatively analyzed. Results The levels of IL-8 and COX-2 from prostate tissue and expressed prostatic secretions were higher in huperplasia with inflammation group than those in simple hyperplasia group （P＆lt;0.01）. The levels of IL-8 and COX-2 in prostate tissue were positively correlated with those in expressed prostatic secretions（r＆gt;0.05）, and IL-8 level in prostate tissue was highly correlated to that of expressed prostatic secretions （r＆gt;0.8）. Conclusion The levels of IL-8 and COX-2 in prostate fluid could indirectly reflect the levels of IL-8 and COX-2 in prostate tissue. A BPH patient with prostatitis can be defined by analyzing the levels of IL-8 and COX-2 in expressed prostatic secretions.